Finasteride - Generic Propecia

Generic Propecia / Finasteride 1mg x 180 pills $119.95 US it’s only $0.67 per pill.
Finasteride is used to treat benign prostatic hyperplasia (enlarged prostate).
www.all-tablet.com

Finasteride is a competitive and specific inhibitor of Type II 5 alpha-reductase, an intracellular enzyme that converts the androgen testosterone into dihydrotestosterone (DHT). Two distinct isozymes of 5 alpha-reductase are found in mice, rats, monkeys, and humans: Type I and II. Each of these isozymes is differentially expressed in tissues and developmental stages. In humans, Type I 5 alpha-reductase is predominant in the sebaceous glands of most regions of skin, including scalp and liver. Type I 5 alpha-reductase is responsible for approximately one-third of circulating DHT. The Type II 5 alpha-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides and hair follicles as well as liver, and is responsible for two-thirds of circulating DHT.

In humans, the mechanism of action of finasteride is based on its preferential inhibition of the Type II isozyme. Using native tissues (scalp and prostate), in vitro binding studies examining the potential of finasteride to inhibit either isozyme revealed a 100-fold selectivity for the human Type II 5 alpha-reductase over Type I isozyme (IC 50=500 and 4.2 nM for Type I and II, respectively). For both isozymes, the inhibition by finasteride is accompanied by reduction of the inhibitor to dihydrofinasteride and adduct formation with NADP +. The turnover for the enzyme complex is slow (t 1Ä2 approximately 30 days for the Type II enzyme complex and 14 days for the Type I complex).

Finasteride has no affinity for the androgen receptor and has no androgenic, antiandrogenic, estrogenic, antiestrogenic, or progestational effects. Inhibition of Type II 5 alpha-reductase blocks the peripheral conversion of testosterone to DHT, resulting in significant decreases in serum and tissue DHT concentrations. Finasteride produces a rapid reduction in serum DHT concentration, reaching 65% suppression within 24 hours of oral dosing with a 1 mg tablet.

In men with male pattern hair loss (androgenetic alopecia), the balding scalp contains miniaturized hair follicles and increased amounts of DHT compared with hairy scalp. Administration of finasteride decreases scalp and serum DHT concentrations in these men. By this mechanism, finasteride interrupts a key factor in the development of androgenetic alopecia in those patients genetically predisposed.

In a study in 15 healthy male subjects, the mean bioavailability of finasteride 1 mg tablets was 65% (range, 26 to 170%), based on the ratio of AUC relative to a 5 mg i.v. dose infused over 60 minutes. Following the i.v. infusion, mean plasma clearance was 165 mL/min (range, 70 to 279 mL/min) and mean steady-state volume of distribution was 76 L (range, 44 to 96 L). In a separate study, the bioavailability of finasteride was not affected by food.

Approximately 90% of circulating finasteride is bound to plasma proteins. Finasteride has been found to cross the blood-brain barrier.

Due to the drug’s effect on male babies, women should avoid Propecia if there is any chance that they may be pregnant.

Do not use Propecia if it gives you an allergic reaction, or if you’ve ever had an allergic reaction to its chemical twin, Proscar.

Propecia is a pill taken by mouth that is a fairly new and effective treatment for male baldness. An increase in scalp hair count and hair regrowth was seen in over 80% of men for whom it was prescribed. Numerous studies have been done looking at the efficacy of PROPECIA. Overall improvements were seen as quickly as 3 months after starting the medicine. PROPECIA not only led to a decrease in hair loss but also significantly increased the rate of hair regrowth. These effects were maintained for over 2 years with continued PROPECIA therapy.

Propecia should be stored at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture. Keep this and all medications out of the reach of children.

This drug is taken by mouth. 1 tablet per day. PROPECIA is the brand name for finasteride, which acts to inhibit the conversion of the androgen (male hormone) testosterone into 5-alpha-dihydrotesterone (DHT). In men each hair follicle contains tiny amounts of DHT. As male pattern baldness begins the amount of DHT contained in each follicle increases. PROPECIA through its inhibitory action serves to reverse this process by decreasing the amount of DHT in the hair follicle and in blood.

In clinical studies adverse reactions were noted to be rare and did not affect most men. The most common adverse reaction was decreased libido that appeared to occur in less then 2.0% of men taking this medicine. The problem quickly resolved in all cases upon the discontinuation of the medication.

If you miss a dose, take it as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not “double-up” the dose to catch up.

A study showed that hair grew in thicker, faster, or both.

PROPECIA grows natural hair, not just “peach fuzz.”

At the end of a 4-year study, there was an increase in the weight of hair samples taken from the men who took PROPECIA compared with hair samples taken from the men who took a placebo (sugar pill).

The effectiveness of PROPECIA was demonstrated in studies of men, aged 18 to 41, with mild to moderate hair loss at the top and middle front of the head. There is not sufficient evidence that PROPECIA works for receding hairlines at the temples.

You may see less hair loss in as little as 3 months.

You will need to take PROPECIA for as long as you want to grow or maintain your hair.

If you stop taking PROPECIA, you will likely lose the hair you have gained within 12 months of stopping treatment.

Available data indicate that the level of PROPECIA in the semen of a man taking PROPECIA does not pose a risk to an unborn child. Accordingly, a man can take PROPECIA while conceiving a child with his partner, or have sexual intercourse with his partner if she is already pregnant.

PROPECIA is for the treatment of male pattern hair loss in MEN ONLY and should NOT be used by women or children.

Women who are or may potentially be pregnant must not use PROPECIA and should not handle crushed or broken tablets of PROPECIA because the active ingredient may cause abnormalities of a male baby’s sex organs. If a woman who is pregnant comes into contact with the active ingredient in PROPECIA, a doctor should be consulted. PROPECIA tablets are coated and will prevent contact with the active ingredient during normal handling, provided that the tablets are not broken or crushed.

In clinical studies for PROPECIA, a small number of men experienced certain sexual side effects, such as less desire for sex, difficulty in achieving an erection, or a decrease in the amount of semen. Each of these side effects occurred in less than 2% of men and went away in men who stopped taking PROPECIA because of them.

2 of 3 men on PROPECIA regrew hair, as measured by hair count.

Simply put, all men who took the placebo (sugar pill) lost hair by the end of the 5-year study.

On the other hand, most men (2 of 3) on PROPECIA gained hair at the end of the 5-year study.

By the end of the study, there was an average difference of 277 hairs in a test spot (1-inch circle on top of head) between men who took PROPECIA and men who took placebo.

Throughout the 5-year study, the difference between the 2 groups increased. The maximum increase in hair count with PROPECIA occurred in the first 2 years of the study.

A 5-year clinical study demonstrated the effectiveness of PROPECIA.

• 9 of 10 men on PROPECIA had visible results (either regrowth of hair, 48% [134 of 279], or no further hair loss, 42% [117 of 279]) vs 25% (4 of 16) on placebo (sugar pill), according to an assessment of photographs by an independent panel of dermatologists.
• 2 of 3 men who took PROPECIA regrew hair, as measured by hair count. All the men in the study who were not taking PROPECIA lost hair.
• A majority of men who took PROPECIA were rated as improved by doctors—77% (210 of 271) vs 15% (2 of 13) with placebo.
• A majority of men who took PROPECIA reported their bald spot getting smaller, their hair loss slowing down, and the appearance of their hair improving.

What’s more, in the first year of the study, 86% (587 of 679) of men who took PROPECIA maintained hair or increased the number of visible hairs vs 42% (282 of 672) who took placebo.

PROPECIA is for MEN ONLY.

Further treatment is unlikely to help if the drug has not worked within 12 months. If you stop taking PROPECIA, you will likely lose the hair you have gained within 12 months of stopping treatment.